Breast Cancer Area: Scientists with Datasets. Github repository
Explore our interactive graph to see how breast cancer scientists work. Learn about their knowledge, the data they use, and the Bridge2AI scientists leading the way.
We use HetGNN (Heterogeneous Graph Neural Network) to represent node embeddings in the Breast Cancer area with the Pubmed Knowledge Graph Dataset. This includes four kinds of nodes: scientists, datasets, papers, and bioentities. Their relationships include writing, collaboration, mention, citing, and use.
We visualized scientists and datasets using K-means clustering (k=5) and T-SNE. The cluster labels are based on bioentities, abstracts, titles, TF-IDF, and chatGPT. At the bottom of this page, we list the main words of each cluster, including both bioentities-based and abstract-title-based clusters.
Bioentities: 'leptin', 'NF-κB', 'ATP', 'MAPK', 'DOX', 'AKT', 'MCF7', 'ERK', 'HBXIP', 'Bax', 'MTT', 'Bcl-2', 'oxygen', 'NF-B', 'CXCR4', 'STAT3', 'p38', 'anticancer', 'curcumin', 'siRNA', 'cisplatin', 'ERα', 'CSCs', 'mTOR', 'p21', 'PEG', 'PTX'
Keywords: 'rgd', 'western', 'anticancer', 'acid', 'investigated', 'apoptosis', 'integrin', 'mechanisms', 'enhanced', 'delivery', 'inhibits', 'nfb', 'present', 'line', 'demonstrated', 'induced', 'inhibit', 'antitumor', 'nanoparticles', 'therapeutic', 'mitochondrial', 'resistance', 'addition', 'drug', 'mechanism', 'assay', 'targeting'
Bioentities: 'overweight', 'folate', 'colorectal cancer', 'insulin', 'BCS', 'postmenopausal breast cancer', 'Tamoxifen', 'testosterone', 'vitamin D', 'MD', 'depression', 'IGF-I', 'anxiety', 'prostate cancer', 'metformin', 'obesity', 'Participants', 'estrogens', '"breast', 'diabetes'
Keywords: 'confidence', 'la', 'rr', 'research', 'embase', 'incidence', 'casecontrol', 'polymorphism', 'science', 'population', 'ratio', 'cohort', 'screening', 'diagnosis', 'will', 'physical', 'care', 'interventions', 'de', 'models', 'published', 'mortality', 'health', 'searched', 'cochrane', 'web', 'intake', 'relationship', 'associations', 'age', 'subgroup', 'les', 'databases', 'odds', 'survivors', 'conducted', 'intervention'
Bioentities: 'ESR1', 'CHEK2', 'CBC', 'ATM', 'BRCA1 mutation', 'PRS', 'ERBB2', 'RNA', 'c', 'AR', 'PALB2', 'breast and ovarian cancer', 'BRCA2 mutations', 'miRNA', 'Estrogen', 'single nucleotide polymorphisms', 'TP53', 'familial breast cancer', 'FGFR2'
Keywords: 'brca2', 'network', 'brca1', 'variants', 'samples', 'mirnas', 'estrogen', 'mutation', 'identify', 'dna', 'differentially', 'functional', 'her2', 'biological', 'common', 'prognosis', 'status', 'er', 'independent', 'genes', 'interaction', 'database', 'impc', 'analyses', 'mutations'
Bioentities: '5-fluorouracil', 'early breast cancer', 'diarrhea', 'fulvestrant', 'SLN', 'pertuzumab', 'bevacizumab', 'taxanes', 'hormone receptor', 'G-CSF', 'palbociclib', 'CTC', 'zoledronic acid', 'everolimus', 'ABC', 'exemestane', 'gemcitabine', 'nausea', 'anthracyclines', 'methotrexate', 'neutropenia', 'vinorelbine', 'lapatinib', 'HER2-positive breast cancer', 'Trastuzumab', 'CMF', 'taxane', 'fluorouracil'
Keywords: 'apbi', 'radiation', 'followup', 'early', 'trial', 'time', 'median', 'patient', 'lesions', 'rate', 'hr', 'trastuzumab', 'adjuvant', 'radiotherapy', 'chemotherapy', 'treated', 'lymphedema', 'recurrence', 'outcome', 'reconstruction', 'only', 'sln', 'node', 'icg', 'neoadjuvant', 'efficacy', 'axillary', 'biopsy', 'advanced', 'os', 'rates', 'plus', 'surgery', 'toxicity', 'mastectomy', 'surgical', 'sentinel', 'randomized', 'months', 'fluorescence'
Bioentities: 'MMPs', 'MT1-MMP', 'TIMP-2', 'uPA', 'TIMP-1', 'carcinomas', 'collagen', 'uPAR', 'steroid', 'matrix metalloproteinases', 'tumor cell', 'MMP-1', 'MMP', 'PAI-1', 'carcinoma'
Keywords: 'carcinomas', 'suggest', 'metastases', 'metalloproteinase', 'serum', 'membrane', 'type', 'metalloproteinases', 'timp2', 'inhibitors', 'stromal', 'degradation', 'bone', 'mmps', 'timp1', 'mrna', 'mmp', 'mt1mmp', 'collagen', 'tumour', 'correlated', 'extracellular', 'mmp1'